Correct Fatty Acids: Critical for Brain Function

Another critical nutrient for optimal mental performance is fatty acids (FAs), as much of the brain is made up of fatty acids. The white matter of the brain is made up largely of myelin, a whitish fatty acid that insulates axons (nerves) for high-speed conduction, also why the "white matter" is white.

All of the membranes of the billions of neurons in the brain are also made of fatty acids, and effective nerve conduction requires the correct type and amount of fatty acids to maintain membrane stability and function. Since Brain Integration relies upon effective, synchronised nerve conduction, Brain Integration also relies directly upon sufficient concentrations of the correct fatty acids being present in the brain.

While fatty acid biochemistry is very complex, I will summarise the salient points with regard to fatty acids in the brain and the roles they play in optimal mental performance. The Difference Between Saturated and Unsaturated Fatty Acids

There two major group of fatty acids: - saturated and unsaturated fatty acids that differ in that the unsaturated fatty acids have one or more double bonds in their structure while saturated fatty acids have none. Because hydrogen atoms saturate all of the bonding sites along the carbon chain of saturated fatty acids, these molecules are relatively "stiff" and not very flexible as fatty acids go. While this is good for structural integrity, it poses problems for functions like neural signalling where membrane flexibility determines efficiency.

In contrast, unsaturated fatty acids have one or more places where the hydrogen atoms are missing and two bonds (or a double bond) connect two adjacent carbon atoms (See Fig. 6 below). The presence of this relatively more flexible double bond means membranes containing unsaturated fatty acids are more fluid and have different properties than membranes made of saturated fatty acids.

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Specific Fatty Acids For The Brain

Unsaturated fatty acids come in several flavours depending upon how many double bonds they possess and where these double bonds are located. Monounsaturated fatty acids like olive oil and evening primrose oil have only one double bond, while polyunsaturated fatty acids like the Omega-3 and Omega-6 fatty acids have more than two double bonds.

Figure 7 shows that Omega-3 and Omega-6 fatty acids differ in the location of their first double bond with the Omega-3 fatty acids having their first double bond at the third carbon atom

 



Figure 6. Saturated and Unsaturated Fatty Acids. Note presence of C=C double bond in
Unsaturated Fatty Acids. Number in parentheses gives number of Carbon atoms:
then number of double bonds, then Omega number (e.g.-9, -6, -3).

 


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Figure 7 shows that Omega-3 and Omega-6 fatty acids differ in the location of their first double bond with the Omega-3 fatty acids having their first double bond at the third carbon atom from the end, and 0mega-6 having it at the sixth carbon atom from the end. All polyunsaturated fatty acids are flexible, but omega-3 fatty acids are much more flexible than Omega-6 fatty acids, and Omega-3 fatty acids predominate in the cortex and at the synapses, the junction between neurons.

 


Figure 7. The Omega-3 & Omega-6, Unsaturated Fatty acids.


 

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